Synthesis of 2-cyclopentenones by gold(I)-catalyzed Rautenstrauch rearrangement.
نویسندگان
چکیده
The rearrangement of 1-ethynyl-2-propenyl pivaloates to cyclopentenones catalyzed by cationic triphenylphosphinegold(I) complexes is described. The reaction tolerates both alkyl and aryl substitution at the acetylenic and olefinic positions. Importantly, the gold(I)-catalyzed rearrangement of enantioenriched propargyl pivaloates proceeds with excellent chirality transfer, thus providing a practical method for the enantioselective synthesis of cyclopentenones.
منابع مشابه
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عنوان ژورنال:
- Journal of the American Chemical Society
دوره 127 16 شماره
صفحات -
تاریخ انتشار 2005